Article
Metal cation mediated-capillary electrophoresis of nucleic acids.
Analytical chemistry - 15 Jan 2010
Li Tao, Zhang Dapeng, Luo Wenru, Lu Meiling, Wang Zhixin, Song Yuling, Wang Hailin
Abstract excerpt
Nucleic acid electrophoresis separation heavily depends upon gel or nongel sieving matrix. Here we propose a metal ion mediated-capillary electrophoresis (MCE-CE) by utilizing the nonspecific interactions of Mg(2+) and Ca(2+) and demonstrate the size, conformation, or sequence based separation and characterization of versatile nucleic acid molecules in free solution. Mg(2+) and Ca(2+) can induce DNA separation at...
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