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Article

Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Bonfield Tracey L, Thomassen Mary Jane, Farver Carol F, Abraham Susamma, Koloze Mary T, Zhang Xia, Mosser David M, Culver Daniel A

Abstract excerpt

Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GM-CSF knockout mouse, a murine model for PAP. A potential regulator of M-CSF, peroxisome proliferator-activated receptor-gamma (PPARgamma), is severely deficient in both human PAP and the GM-CSF knockout mouse. To investigate...

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Identifiers

PMID: 18566389
DOI: 10.4049/jimmunol.181.1.235
PMCID: PMC2819287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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