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Article

Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.

European journal of immunology - 1 Apr 2008

Liu Tian-Yi, Uemura Yasushi, Suzuki Motoharu, Narita Yayoi, Hirata Shinya, Ohyama Hideki, Ishihara Osamu, Matsushita Sho

Abstract excerpt

Invariant natural killer T (iNKT) cells regulate the T helper (Th) 1/2 balance and elicit either enhancement or suppression of the immune responses. However, the exact mechanism by which iNKT cells exert these contrasting functions has remained elusive. We demonstrate herein that two major distinct subsets of human iNKT cells, CD4+CD8beta(-) (CD4+) and CD4(-)CD8beta(-) (double negative; DN) cells, express...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18350544
DOI: 10.1002/eji.200737838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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