Article
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Blood - 8 Aug 2013
Nizzoli Giulia, Krietsch Jana, Weick Anja, Steinfelder Svenja, Facciotti Federica, Gruarin Paola, Bianco Annalisa, Steckel Bodo, Moro Monica, Crosti Mariacristina, Romagnani Chiara, Stölzel Katharina, Torretta Sara, Pignataro Lorenzo, Scheibenbogen Carmen, Neddermann Petra, De Francesco Raffaele, Abrignani Sergio, Geginat Jens
Abstract excerpt
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α(+)DC are specialized to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity. Human BDCA-3(+)DC share several relevant characteristics with CD8α(+)DC, but the capacities of human DC subsets to induce CD8(+) T-cell responses are incompletely understood. Here we compared CD1c(+)...
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