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Article

Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1995

Hagerty D T, Allen P M

Abstract excerpt

The recognition of peptide Ags by T cells through the TCR has exquisite specificity. Cross-reactive T cell responses have been described; however, the structural basis for these responses is not known. We show that two peptides derived from the same protein can exhibit sufficient structural homology, despite minimal structural identity, to elicit cross-reactive T cell responses. In addition, we explore the...

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PMID: 7673717

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