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Article

Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1995

Hagerty D T, Allen P M

Abstract excerpt

The recognition of peptide Ags by T cells through the TCR has exquisite specificity. Cross-reactive T cell responses have been described; however, the structural basis for these responses is not known. We show that two peptides derived from the same protein can exhibit sufficient structural homology, despite minimal structural identity, to elicit cross-reactive T cell responses. In addition, we explore the...

Topics

Alleles
Amino Acid Sequence
Animals
Cross Reactions
Epitope Mapping
Humans
Hybridomas
Mice
Mice, Transgenic
Molecular Sequence Data
Sequence Alignment
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

alpha 1-Antitrypsin

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Identifiers

PMID: 7673717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7673717-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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