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Article

Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones.

Journal of virology - 15 Aug 2018

Balamurugan Arumugam, Ng Hwee L, Yang Otto O

Abstract excerpt

Although a high level of promiscuity for heterologous epitopes is believed to exist for cellular immunity, limited data explore this issue for human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T lymphocyte (CTL) responses. Here, we found an unexpected degree of heterologous cross-reactivity against HIV-1 epitopes, in addition to the targeted index epitope. Most CTL clones screened cross-reacted against...

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Share to Cells, Cultured
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

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Identifiers

PMID: 29899094
DOI: 10.1128/JVI.00617-18
PMCID: PMC6069174

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