Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy

4 Oct 2017

Abstract excerpt

Immunotherapy has become one of the most promising avenues for cancer treatment, making use of the patient's own immune system to eliminate cancer cells. Clinical trials with T-cell-based immunotherapies have shown dramatic tumor regressions, being effective in multiple cancer types and for many different patients. Unfortunately, this progress was tempered by reports of serious (even fatal) side effects. Such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29046675
DOI: 10.3389/fimmu.2017.01210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer ImmunotherapyPMID 29046675Read ↗

T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translationSemantic proximity Read ↗

T‐cell cross‐reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitorsSemantic proximity Read ↗

Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire.Semantic proximity Read ↗

TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide–HLA ComplexSemantic proximity Read ↗

Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognitionSemantic proximity Read ↗

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens.Semantic proximity Read ↗

Analysis of tumor-derived and cross-presented peptide antigens defines improved immunotherapeutic strategiesSemantic proximity Read ↗

Antigen Cross-Presentation of Immune ComplexesSemantic proximity Read ↗

TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependenceSemantic proximity Read ↗

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humansSemantic proximity Read ↗

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanomaSemantic proximity Read ↗

Bioinformatic analysis of shared B and T cell epitopes amongst relevant coronaviruses to human health: Is there cross-protection?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.