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Article

Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.

Molecular biology of the cell - 1 Dec 2007

Zhong Bihui, Strnad Pavel, Toivola Diana M, Tao Guo-Zhong, Ji Xuhuai, Greenberg Harry B, Omary M Bishr

Abstract excerpt

The major keratins in the pancreas and liver are keratins 8 and 18 (K8/K18), but their function seemingly differs in that liver K8/K18 are essential cytoprotective proteins, whereas pancreatic K8/K18 are dispensable. This functional dichotomy raises the hypothesis that K8-null pancreata may undergo compensatory cytoprotective gene expression. We tested this hypothesis by comparing the gene expression profile in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17898082
DOI: 10.1091/mbc.e07-02-0180
PMCID: PMC2096595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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