Article
DNA double-strand breaks: a potential causative factor for mammalian aging?
Mechanisms of ageing and development - 1 Jan 2000
Li Han, Mitchell James R, Hasty Paul
Abstract excerpt
Aging is a pleiotropic and stochastic process influenced by both genetics and environment. As a result the fundamental underlying causes of aging are controversial and likely diverse. Genome maintenance and in particular the repair of DNA damage is critical to ensure longevity needed for reproduction and as a consequence imperfections or defects in maintaining the genome may contribute to aging. There are many...
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