Article
Genome Instability and DNA Repair in Somatic and Reproductive Aging.
Annual review of pathology - 24 Jan 2024
Panier Stephanie, Wang Siyao, Schumacher Björn
Abstract excerpt
Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires maintenance during an individual's lifespan, while the germline indefinitely perpetuates its genetic information. DNA lesions are recognized and repaired by mechanistically highly diverse repair machineries. The DNA damage...
Topics
- Humans
- Aging
- DNA Repair
- Genomic Instability
- Mutation
- Apoptosis