Article
DNA double strand break repair, aging and the chromatin connection.
Mutation research - 1 Jun 2016
Gorbunova Vera, Seluanov Andrei
Abstract excerpt
Are DNA damage and mutations possible causes or consequences of aging? This question has been hotly debated by biogerontologists for decades. The importance of DNA damage as a possible driver of the aging process went from being widely recognized to then forgotten, and is now slowly making a comeback. DNA double strand breaks (DSBs) are particularly relevant to aging because of their toxicity, increased frequency...
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