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Article

Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents.

PloS one - 12 Mar 2008

Desrivières Sylvane, Krause Kristina, Dyer Anne, Frank Josef, Blomeyer Dorothea, Lathrop Mark, Mann Karl, Banaschewski Tobias, Laucht Manfred, Schumann Gunter

Abstract excerpt

BACKGROUND: While the phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is typically known to regulate cell growth and survival, emerging evidence suggest a role for this pathway in regulating the behavioural responses to addictive drugs. METHODOLOGY/PRINCIPAL FINDINGS: To investigate whether PI3K contributes to patterns of risky alcohol drinking in human, we investigated genetic variations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18335044
DOI: 10.1371/journal.pone.0001769
PMCID: PMC2262154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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