Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2002

Liolitsa D, Powell J, Lovestone S

Abstract excerpt

OBJECTIVE: To test the hypothesis that polymorphic variation in insulin signalling genes may underlie the shared risk of dysfunctional insulin signalling and late onset Alzheimer's disease (AD). The p85alpha subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved in insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Alzheimer Disease
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Resistance

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 12185156
DOI: 10.1136/jnnp.73.3.261
PMCID: PMC1738023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.PMID 12185156Read ↗

Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms?Semantic proximity Read ↗

Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.Semantic proximity Read ↗

Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.Semantic proximity Read ↗

Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.Semantic proximity Read ↗

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer's Disease.Semantic proximity Read ↗

Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.Semantic proximity Read ↗

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia.Semantic proximity Read ↗

IGF-I gene variability is associated with an increased risk for AD.Semantic proximity Read ↗

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.