Article
Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.
Alcoholism, clinical and experimental research - 1 Jun 2018
Lee Ji Soo, Sorcher Jill L, Rosen Allison D, Damadzic Ruslan, Sun Hui, Schwandt Melanie, Heilig Markus, Kelly John, Mauro Kelsey L, Luo Audrey, Rosoff Daniel, Muench Christine, Jung Jeesun, Kaminsky Zachary A, Lohoff Falk W
Abstract excerpt
BACKGROUND: The gene encoding phosphatidylinositol-4-phosphate 5-kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD....
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