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Article

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.

Human reproduction (Oxford, England) - 1 May 2009

Kim Jin Ju, Choi Young Min, Hong Min A, Hwang Seung Sik, Yoon Sang Ho, Chae Soo Jin, Jee Byung Chul, Ku Seung Yup, Kim Jung Gu, Moon Shin Yong

Abstract excerpt

BACKGROUND: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS). Phosphatidylinositol (PI) 3-kinase is an important enzyme in the early insulin signaling cascade and plays a key role in insulin-mediated glucose transport. In its regulatory subunit, p85alpha, there is a common amino acid substitution (the Met326Ile polymorphism), and this amino acid may be crucial for the function of the...

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PMID: 19218574
DOI: 10.1093/humrep/dep019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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