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Article

The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity.

Developmental biology - 15 Apr 2008

Kwon So Yeon, Xiao Hua, Glover Bradley P, Tjian Robert, Wu Carl, Badenhorst Paul

Abstract excerpt

The Drosophila nucleosome remodeling factor (NURF) is an ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF has the ability to alter chromatin structure and regulate transcription. Previous studies have shown that mutation of Drosophila NURF induces melanotic tumors, implicating NURF in innate immune function. Here, we show that NURF mutants...

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PMID: 18334252
DOI: 10.1016/j.ydbio.2008.01.033

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