Article
The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.
EMBO reports - 1 Feb 2008
Carré Clément, Ciurciu Anita, Komonyi Orbán, Jacquier Caroline, Fagegaltier Delphine, Pidoux Josette, Tricoire Hervé, Tora Laszlo, Boros Imre M, Antoniewski Christophe
Abstract excerpt
Drosophila Gcn5 is the catalytic subunit of the SAGA and ATAC histone acetylase complexes. Here, we show that mutations in Gcn5 and the ATAC component Ada2a induce a decondensation of the male X chromosome, similar to that induced by mutations in the Iswi and Nurf301 subunits of the NURF nucleosome remodelling complex. Genetic studies as well as transcript profiling analysis indicate that ATAC and NURF regulate...
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