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Article

Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF.

Cell stem cell - 4 Jun 2010

Cherry Christopher M, Matunis Erika L

Abstract excerpt

Regulation of stem cells depends on both tissue-specific transcriptional regulators and changes in chromatin organization, yet the coordination of these events in endogenous niches is poorly understood. In the Drosophila testis, local JAK-STAT signaling maintains germline and somatic stem cells (GSCs and cyst progenitor cells, or CPCs) in a single niche. Here we show that epigenetic regulation via the...

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Chromatin Assembly and Disassembly
Embryonic Stem Cells
Janus Kinases
Spermatogenesis
STAT Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stem Cell Niche

Suppressor of Cytokine Signaling Proteins

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PMID: 20569693
DOI: 10.1016/j.stem.2010.04.018
PMCID: PMC2897240

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GSC

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