Article
Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growth.
Infection and immunity - 1 May 2008
Hunt Debbie M, Saldanha José W, Brennan John F, Benjamin Pearline, Strom Molly, Cole Jeffrey A, Spreadbury Claire L, Buxton Roger S
Abstract excerpt
Single nucleotide polymorphisms (SNPs) are present in the global transcriptional regulator cyclic AMP (cAMP) receptor protein (CRP) of the attenuated vaccine strain Mycobacterium bovis, bacillus Calmette-Guérin (BCG). We have found that these SNPs resulted in small but significant changes in the expression of a number of genes in M. tuberculosis when a deletion of the Rv3676 CRP was complemented by the BCG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.