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Article

Paralogous cAMP receptor proteins in Mycobacterium smegmatis show biochemical and functional divergence.

Biochemistry - 16 Dec 2014

Sharma Ritu, Zaveri Anisha, Gopalakrishnapai Jayashree, Srinath Thiruneelakantan, Thiruneelakantan Srinath, Varshney Umesh, Visweswariah Sandhya S

Abstract excerpt

The cyclic AMP receptor protein (CRP) family of transcription factors consists of global regulators of bacterial gene expression. Here, we identify two paralogous CRPs in the genome of Mycobacterium smegmatis that have 78% identical sequences and characterize them biochemically and functionally. The two proteins (MSMEG_0539 and MSMEG_6189) show differences in cAMP binding affinity, trypsin sensitivity, and...

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PMID: 25434596
DOI: 10.1021/bi500924v

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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