Article
Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.
Microbiology (Reading, England) - 1 Jul 2010
Mendoza Lopez Pablo, Golby Paul, Wooff Esen, Garcia Javier Nunez, Garcia Pelayo M Carmen, Conlon Kevin, Gema Camacho Ana, Hewinson R Glyn, Polaina Julio, Suárez García Antonio, Gordon Stephen V
Abstract excerpt
A number of single-nucleotide polymorphisms (SNPs) have been identified in the genome of Mycobacterium bovis BCG Pasteur compared with the sequenced strain M. bovis 2122/97. The functional consequences of many of these mutations remain to be described; however, mutations in genes encoding regulators may be particularly relevant to global phenotypic changes such as loss of virulence, since alteration of a...
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