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Convergence of two global regulators to coordinate expression of essential virulence determinants of <i>Mycobacterium tuberculosis</i>

2022-06-30

Abstract excerpt

Cyclic AMP (cAMP) is known to function as a global regulator of M. tuberculosis gene expression. Sequence-based transcriptomic profiling identified the mycobacterial regulon controlled by the cAMP receptor protein, CRP. In this study, we identified a new subset of CRP-associated genes including virulence determinants which are also under the control of a major regulator, PhoP. Our results suggest that PhoP as a D...

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Literature Corpus work
cdd7a659-2c23-5173-a5c7-112fed2a617b
DOI
10.1101/2022.06.30.498252
Open publication

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Convergence of two global regulators to coordinate expression of essential virulence determinants of <i>Mycobacterium tuberculosis</i>DOI 10.1101/2022.06.30.498252
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