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The BCG Moreau RD16 deletion inactivates a repressor reshaping transcription of an adjacent gene.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2014

Galvão Teca Calcagno, Lima Cristiane Rodrigues, Gomes Leonardo Henrique Ferreira, Pagani Talita Duarte, Ferreira Marcelo Alves, Gonçalves Antonio S, Correa Paloma Rezende, Degrave Wim Maurits, Mendonça-Lima Leila

Abstract excerpt

The Brazilian anti-tuberculosis vaccine strain Mycobacterium bovis bacillus Calmette-Guérin (BCG) BCG Moreau is unique in having a deletion of 7608 bp (RD16) that results in the truncation of a putative TetR transcriptional regulator, the ortholog of Mycobacterium tuberculosis rv3405c, BCG_M3439c. We investigated the effect of this truncation on the expression of the rv3406 ortholog (BCG_M3440), lying 81 bp...

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PMID: 24332305
DOI: 10.1016/j.tube.2013.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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