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Article

Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits.

Molecular and cellular biology - 1 May 2008

White Joshua, Li Zhihua, Sardana Richa, Bujnicki Janusz M, Marcotte Edward M, Johnson Arlen W

Abstract excerpt

BUD23 was identified from a bioinformatics analysis of Saccharomyces cerevisiae genes involved in ribosome biogenesis. Deletion of BUD23 leads to severely impaired growth, reduced levels of the small (40S) ribosomal subunit, and a block in processing 20S rRNA to 18S rRNA, a late step in 40S maturation. Bud23 belongs to the S-adenosylmethionine-dependent Rossmann-fold methyltransferase superfamily and is related...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to RNA, Ribosomal, 18S

Source

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Identifiers

PMID: 18332120
DOI: 10.1128/MCB.01674-07
PMCID: PMC2423152

Genes

BUD23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits.PMID 18332120Read ↗

The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits.Semantic proximity Read ↗

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.Semantic proximity Read ↗

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.Semantic proximity Read ↗

The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP.Semantic proximity Read ↗

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Physical and functional interaction between the methyltransferase Bud23 and the essential DEAH-box RNA helicase Ecm16.Semantic proximity Read ↗

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesisSemantic proximity Read ↗

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Genetic evidence for 18S rRNA binding and an Rps19p assembly function of yeast nucleolar protein Nep1p.Semantic proximity Read ↗

Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

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