Article
Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.
PloS one - 3 May 2010
Bellemer Clément, Chabosseau Pauline, Gallardo Franck, Gleizes Pierre-Emmanuel, Stahl Guillaume
Abstract excerpt
Rps15p, an essential ribosomal protein, was previously shown to be critical for nuclear export of small subunit pre-particles. We have designed a synthetic lethal screen in Saccharomyces cerevisiae to identify its genetic partners and further elucidate its role during ribosomal biogenesis. Our screen revealed interactions with mutants affected at various stages during ribosome biogenesis, from early nucleolar...
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