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WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N<sup>7</sup>-methylation of G1639 in human 18S rRNA

18 Dec 2014

Abstract excerpt

Ribosomal (r)RNAs are extensively modified during ribosome synthesis and their modification is required for the fidelity and efficiency of translation. Besides numerous small nucleolar RNA-guided 2'-O methylations and pseudouridinylations, a number of individual RNA methyltransferases are involved in rRNA modification. WBSCR22/Merm1, which is affected in Williams-Beuren syndrome and has been implicated in...

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PMID: 25525153
DOI: 10.1261/rna.047910.114

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