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Article

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.

RNA (New York, N.Y.) - 1 Jul 2009

Lindahl Lasse, Bommankanti Ananth, Li Xing, Hayden Lauren, Jones Adrienne, Khan Miriam, Oni Tolulope, Zengel Janice M

Abstract excerpt

RNase MRP is a nucleolar RNA-protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested that RNase MRP makes a nonessential cleavage in the first internal transcribed spacer. Here we report experiments with new temperature-sensitive RNase MRP mutants in Saccharomyces cerevisiae that show that the abundance of all early intermediates in the processing...

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Identifiers

PMID: 19465684
DOI: 10.1261/rna.1302909
PMCID: PMC2704079

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Source receipt: pubmed, retrieved 7 Sept 2026.

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