Article
Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.
The EMBO journal - 1 Nov 1991
Jessen T H, Oubridge C, Teo C H, Pritchard C, Nagai K
Abstract excerpt
We recently determined the crystal structure of the RNP domain of the U1 small nuclear ribonucleoprotein A and identified Arg and Lys residues involved in U1 RNA binding. These residues are clustered around the two highly conserved segments, RNP1 and RNP2, located in the central two beta strands. We have now studied the U1 RNA binding of mutants where potentially hydrogen bonding residues on the RNA binding...
Topics
- Base Sequence
- Binding Sites
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Small Nuclear
- Ribonucleoproteins
- Ribonucleoproteins, Small Nuclear