Article
Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.
Molecular and cellular biology - 1 Mar 2000
Klein Gunnewiek J M, Hussein R I, van Aarssen Y, Palacios D, de Jong R, van Venrooij W J, Gunderson S I
Abstract excerpt
It was previously shown that the human U1A protein, one of three U1 small nuclear ribonucleoprotein-specific proteins, autoregulates its own production by binding to and inhibiting the polyadenylation of its own pre-mRNA. The U1A autoregulatory complex requires two molecules of U1A protein to cooperatively bind a 50-nucleotide polyadenylation-inhibitory element (PIE) RNA located in the U1A 3' untranslated region....
Topics
- Amino Acid Sequence
- Binding Sites
- Dimerization
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- RNA
- RNA-Binding Proteins
- Ribonucleoprotein, U1 Small Nuclear