Article
Analysis of in vitro binding of U1-A protein mutants to U1 snRNA.
Nucleic acids research - 11 Sept 1991
Boelens W, Scherly D, Jansen E J, Kolen K, Mattaj I W, van Venrooij W J
Abstract excerpt
Despite the great sequence similarity between U1A and U2B", both proteins do have a difference in RNA binding specificity and in the way they bind to their cognate RNAs. The U1A protein is able to bind in vitro U1 RNA independently of other factors. The U2B" protein binds specifically to U2 RNA i...
Topics
- Binding Sites
- Binding, Competitive
- Cloning, Molecular
- Humans
- Mutation
- Nucleic Acid Conformation
- RNA, Small Nuclear
- Ribonucleoproteins
- Ribonucleoproteins, Small Nuclear