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Article

Analysis of in vitro binding of U1-A protein mutants to U1 snRNA.

Nucleic acids research - 11 Sept 1991

Boelens W, Scherly D, Jansen E J, Kolen K, Mattaj I W, van Venrooij W J

Abstract excerpt

Despite the great sequence similarity between U1A and U2B", both proteins do have a difference in RNA binding specificity and in the way they bind to their cognate RNAs. The U1A protein is able to bind in vitro U1 RNA independently of other factors. The U2B" protein binds specifically to U2 RNA in the presence of the U2A' protein only. We have compared the effect on RNA binding of multiple double point mutations...

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Source

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Identifiers

PMID: 1832492
DOI: 10.1093/nar/19.17.4611
PMCID: PMC328699

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Source receipt: pubmed, retrieved 7 Sept 2026.

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