Article
The targeting of β-cells by T lymphocytes in human type 1 diabetes: clinical perspectives.
Diabetes, obesity & metabolism - 1 Sept 2013
Luce S, Briet C, Bécourt C, Lemonnier F, Boitard C
Abstract excerpt
This review focuses on genes that control β-cell targeting in autoimmune, type 1-dependent, diabetes (T1D) and on insulin as the major autoantigen recognized by T lymphocytes throughout the disease process. T1D associates with multiple gene variants. Beyond genes that predispose to general failure of immune tolerance to self, loci identified by the analysis of crosses between non-obese diabetic (NOD) and...
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