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Article

Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Motta Vinicius N, Markle Janet G M, Gulban Omid, Mortin-Toth Steven, Liao Kuo-Chien, Mogridge Jeremy, Steward Charles A, Danska Jayne S

Abstract excerpt

Type 1 diabetes in the NOD mouse model has been linked to >30 insulin-dependent diabetes (Idd) susceptibility loci. Idd4 on chromosome 11 consists of two subloci, Idd4.1 and Idd4.2. Using congenic analysis of alleles in NOD and NOD-resistant (NOR) mice, we previously defined Idd4.1 as an interval containing >50 genes that controlled expression of genes in the type 1 IFN pathway. In this study, we report refined...

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PMID: 25964492
DOI: 10.4049/jimmunol.1400913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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