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Article

Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.

PLoS genetics - 1 Mar 2013

Pronovost Stephen M, Beckerle Mary C, Kadrmas Julie L

Abstract excerpt

A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary conservation allows genetic studies in Drosophila melanogaster to be used to better understand these myopathies and suggest novel therapeutic strategies. Integrin-mediated adhesion is required to support muscle structure and function, and expression of Integrin adhesive complex (IAC) proteins is modulated to adapt to...

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Identifiers

PMID: 23555310
DOI: 10.1371/journal.pgen.1003406
PMCID: PMC3610608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.PMID 23555310Read ↗

Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes.Semantic proximity Read ↗

Requirement for PINCH in Skeletal Myoblast DifferentiationSemantic proximity Read ↗

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The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.Semantic proximity Read ↗

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The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.Semantic proximity Read ↗

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