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Article

Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.

BMC bioinformatics - 6 Mar 2008

Mechanic Leah E, Luke Brian T, Goodman Julie E, Chanock Stephen J, Harris Curtis C

Abstract excerpt

BACKGROUND: The risk of common diseases is likely determined by the complex interplay between environmental and genetic factors, including single nucleotide polymorphisms (SNPs). Traditional methods of data analysis are poorly suited for detecting complex interactions due to sparseness of data in high dimensions, which often occurs when data are available for a large number of SNPs for a relatively small number...

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Identifiers

PMID: 18325117
DOI: 10.1186/1471-2105-9-146
PMCID: PMC2335300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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