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Article

Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.

Circulation research - 25 Apr 2008

Hughes Jeniter E, Srinivasan Suseela, Lynch Kevin R, Proia Richard L, Ferdek Pawel, Hedrick Catherine C

Abstract excerpt

Activated macrophages acquire a proinflammatory (classic) or antiinflammatory (alternative) phenotype that influences atherosclerosis. The present study investigated whether sphingosine-1-phosphate (S1P), with its known antiinflammatory effects, could regulate the inflammatory phenotype of lipopolysaccharide (LPS)-stimulated mouse macrophages. Activation of macrophages by LPS significantly increases...

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Identifiers

PMID: 18323526
DOI: 10.1161/CIRCRESAHA.107.170779
PMCID: PMC2875063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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