Article

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

2020-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Obesity is associated with elevated levels of TNF-α and proinflammatory CD11c monocytes /macrophages. TNF-α mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, including metabolic syndrome, but the underlying mechanisms are incompletely understood. Since neutral sphingomyelinase 2 (nSMase2; product of the sphingomye...

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Literature Corpus work: b4da895f-83c8-51df-91fe-0931db3cbcc5
DOI: 10.1101/2020.05.06.080382

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