Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E induces antiinflammatory phenotype in macrophages.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2011

Baitsch Daniel, Bock Hans H, Engel Thomas, Telgmann Ralph, Müller-Tidow Carsten, Varga Georg, Bot Martine, Herz Joachim, Robenek Horst, von Eckardstein Arnold, Nofer Jerzy-Roch

Abstract excerpt

OBJECTIVE: Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages. METHODS AND RESULTS: Human apoE receptors very-low-density lipoprotein receptor (VLDL-R) and apoE receptor-2 (apoER2) were stably expressed in RAW264.7 mouse macrophages. In these cells, apoE downregulated markers of the proinflammatory M1 phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Inflammation Mediators

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to LDL-Receptor Related Proteins

Share to p38 Mitogen-Activated Protein Kinases

Share to Poly I-C

Share to Protein-Tyrosine Kinases

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 21350196
DOI: 10.1161/ATVBAHA.111.222745
PMCID: PMC3529398

Genes

SOCS3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E induces antiinflammatory phenotype in macrophages.PMID 21350196Read ↗

Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages.Semantic proximity Read ↗

Pravastatin polarizes the phenotype of macrophages toward M2 and elevates serum cholesterol levels in apolipoprotein E knockout mice.Semantic proximity Read ↗

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of InflammationSemantic proximity Read ↗

Understanding the role of alternative macrophage phenotypes in human atherosclerosis.Semantic proximity Read ↗

Macrophage phenotypes in atherosclerosis.Semantic proximity Read ↗

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis.Semantic proximity Read ↗

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2.Semantic proximity Read ↗

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE-/- Mice.Semantic proximity Read ↗

LXRα is expressed at higher levels in healthy people compared to atherosclerosis patients and its over-expression polarizes macrophages towards an anti-inflammatory MΦ2 phenotype.Semantic proximity Read ↗

M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human AtherosclerosisSemantic proximity Read ↗

Apolipoprotein E deficiency leads to the polarization of splenic macrophages towards M1 phenotype by increasing iron content.Semantic proximity Read ↗

Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.