Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway.

Inflammation - 1 Aug 2016

Liu Xinxin, Li Ji, Peng Xiaohong, Lv Bo, Wang Peng, Zhao Xiaoming, Yu Bo

Abstract excerpt

M1 macrophage polarization is proved to promote inflammation in atherosclerosis process. In this study, we evaluated the inhibitory effect of geraniin, a bioactive polyphenolic compound, on the LPS-induced switch of THP-1 macrophages to M1 phenotype, and we propose a molecular basis for its action. Flow cytometry analysis indicated that geraniin significantly inhibited LPS-induced M1 macrophage polarization....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to Gene Expression Regulation
Share to Glucosides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharides

Share to Macrophages

Share to NF-kappa B

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Transcription Factor RelA

Source

Identifiers

PMID: 27290719
DOI: 10.1007/s10753-016-0374-7

Genes

SOCS1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway.PMID 27290719Read ↗

Salvianolic acid B inhibits RAW264.7 cell polarization towards the M1 phenotype by inhibiting NF-κB and Akt/mTOR pathway activation.Semantic proximity Read ↗

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors.Semantic proximity Read ↗

Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation.Semantic proximity Read ↗

Luteolin Alters Macrophage Polarization to Inhibit Inflammation.Semantic proximity Read ↗

Reprogramming M1-to-M2 Phenotype to Alleviate Inflammation: Using Liposomal Curcumin as a Tool to Redefine Macrophage Functionality.Semantic proximity Read ↗

SOCS molecules: the growing players in macrophage polarization and functionSemantic proximity Read ↗

Hydroxychloroquine ameliorates DSS-induced colitis by inhibiting M1 macrophage polarization through NF-κB/NLRP3 signaling pathwaySemantic proximity Read ↗

[Anti-inflammation of simvastatin by polarization of murine macrophages from M1 phenotype to M2 phenotype].Semantic proximity Read ↗

[Inhibitory effects of pseudolaric acid B on inflammatory response and M1 phenotype polarization in RAW264.7 macrophages induced by lipopolysaccharide].Semantic proximity Read ↗

Ginsenoside Rb1 enhances atherosclerotic plaque stability by skewing macrophages to the M2 phenotype.Semantic proximity Read ↗

Quercetin Promotes the M1-to-M2 Macrophage Phenotypic Switch During Liver Fibrosis Treatment by Modulating the JAK2/STAT3 Signaling Pathway.Semantic proximity Read ↗

Eicosanoid production by macrophages during inflammation depends on the M1/M2 phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.