Article
Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.
Neuro-degenerative diseases - 1 Jan 2008
Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen R L, Soininen H
Abstract excerpt
BACKGROUND: The apolipoprotein E (APOE) epsilon4 allele is a risk factor for Alzheimer's disease. Earlier studies have shown differences in brain structure according to the APOE epsilon4 status. OBJECTIVE: To assess possible differences in brain structure according to the APOE epsilon4 status in...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein E4
- Atrophy
- Brain Mapping
- Cerebral Cortex
- Cognition Disorders
- Cohort Studies
- Dementia
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies