Article
Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE levels in early childhood.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Feb 2008
Williams L Keoki, Oliver Jennifer, Peterson Edward L, Bobbitt Kevin R, McCabe Michael J, Smolarek Derek, Havstad Suzanne L, Wegienka Ganesa, Burchard Esteban G, Ownby Dennis R, Johnson Christine C
Abstract excerpt
BACKGROUND: Innate immune system stimuli, such as endotoxin, seem to affect allergy risk. Previously, we described gene-environment interactions between the endotoxin receptor polymorphism C-260T of the CD14 gene and endotoxin exposure on total serum IgE level; however, the mechanism of this interaction is not known. OBJECTIVE: To examine whether this gene-environment interaction affects early CD4(+)Foxp3(-) or...
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