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Article

Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood.

The Journal of allergy and clinical immunology - 1 Aug 2010

Bottema Renske W B, Kerkhof Marjan, Reijmerink Naomi E, Thijs Carel, Smit Henriette A, van Schayck Constant P, Brunekreef Bert, van Oosterhout Antoon J, Postma Dirkje S, Koppelman Gerard H

Abstract excerpt

BACKGROUND: Regulatory T-cell dysfunction is associated with development of the complex genetic conditions atopy and asthma. Therefore, we hypothesized that single nucleotide polymorphisms in genes involved in the development and function of regulatory T cells are associated with atopy and asthma...

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Source

Identifiers

PMID: 20599261
DOI: 10.1016/j.jaci.2010.04.024

Genes

TGFBR2
FOXP3
TLR2
HMOX1
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20599261-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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