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Article

Gene-environment interactions influence airways function in laboratory animal workers.

The Journal of allergy and clinical immunology - 1 Aug 2010

Pacheco Karin A, Rose Cecile S, Silveira Lori J, Van Dyke Michael V, Goelz Kelly, MacPhail Kristyn, Maier Lisa A

Abstract excerpt

BACKGROUND: Most diseases, including asthma, result from the interaction between environmental exposures and genetic variants. Functional variants of CD14 negatively affect lung function in farm workers and children exposed to animal allergens and endotoxin. OBJECTIVE: We hypothesized that CD14 polymorphisms interact with inhaled endotoxin, mouse allergen, or both to decrease airways function in laboratory animal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20579716
DOI: 10.1016/j.jaci.2010.04.019
PMCID: PMC2917520

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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