Article
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
The British journal of nutrition - 1 Dec 2010
Zietemann Vera, Kröger Janine, Enzenbach Cornelia, Jansen Eugene, Fritsche Andreas, Weikert Cornelia, Boeing Heiner, Schulze Matthias B
Abstract excerpt
Delta-5 (D5D) and delta-6 (D6D) desaturases are key enzymes in PUFA metabolism. Several factors (e.g. hyperglycaemia, hypertension, blood lipids, statins and fatty acids in diet and biological tissues) may influence desaturase activity. The goals were to evaluate the associations between variation in genes encoding these desaturases (FADS1 and FADS2) and blood concentrations of n-6 PUFA and estimated D5D and D6D...
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