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Article

MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.

Cancer research - 1 Mar 2008

Bemis Lynne T, Chen Robert, Amato Carol M, Classen Elizabeth H, Robinson Steven E, Coffey David G, Erickson Paul F, Shellman Yiqun G, Robinson William A

Abstract excerpt

Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function. Frequent alteration in the expression of MITF is detected in melanoma, but the mechanism(s) underlying the alteration in expression have not been completely determined....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18316599
DOI: 10.1158/0008-5472.CAN-07-2912

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18316599-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.PMID 18316599Read ↗

Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal MelanomaSemantic proximity Read ↗

MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.Semantic proximity Read ↗

MITF: master regulator of melanocyte development and melanoma oncogene.Semantic proximity Read ↗

Low Expression of Mir-137 Predicts Poor Prognosis in Cutaneous Melanoma PatientsSemantic proximity Read ↗

Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal MelanomaSemantic proximity Read ↗

MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expressionSemantic proximity Read ↗

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Semantic proximity Read ↗

A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo.Semantic proximity Read ↗

Biology and Clinical Relevance of the Micropthalmia Family of Transcription Factors in Human CancerSemantic proximity Read ↗

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen speciesSemantic proximity Read ↗

Microphthalmia transcription factorSemantic proximity Read ↗

Frequent mutations in the MITF pathway in melanoma.Semantic proximity Read ↗

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