Article

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species

2023-11-14

Abstract excerpt

Microphthalmia-associated transcription factor (MITF) plays pivotal roles in melanocyte development, function, and melanoma pathogenesis. MITF amplification occurs in melanoma and has been associated with resistance to targeted therapies. Here, we show that MITF regulates a global antioxidant program that increases survival of melanoma cell lines by protecting the cells from reactive oxygen species (ROS)-induced d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 418e1dcb-5fc7-5d7c-8d11-6e1395809477
DOI: 10.1101/2023.11.10.564582

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen speciesDOI 10.1101/2023.11.10.564582Read

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.Semantic proximity Read

MITF: master regulator of melanocyte development and melanoma oncogene.Semantic proximity Read

A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo.Semantic proximity Read

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Semantic proximity Read

FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cellsSemantic proximity Read

The MITF regulatory network in melanomaSemantic proximity Read

Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.Semantic proximity Read

MITF, the Janus transcription factor of melanoma.Semantic proximity Read

Lighting a path to pigmentation: mechanisms of MITF induction by UVSemantic proximity Read

Wild-type IDH1 inhibition enhances chemotherapy response in melanomaSemantic proximity Read

Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation.Semantic proximity Read

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read