Article
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
Nature - 7 Jul 2005
Garraway Levi A, Widlund Hans R, Rubin Mark A, Getz Gad, Berger Aaron J, Ramaswamy Sridhar, Beroukhim Rameen, Milner Danny A, Granter Scott R, Du Jinyan, Lee Charles, Wagner Stephan N, Li Cheng, Golub Todd R, Rimm David L, Meyerson Matthew L, Fisher David E, Sellers William R
Abstract excerpt
Systematic analyses of cancer genomes promise to unveil patterns of genetic alterations linked to the genesis and spread of human cancers. High-density single-nucleotide polymorphism (SNP) arrays enable detailed and genome-wide identification of both loss-of-heterozygosity events and copy-number alterations in cancer. Here, by integrating SNP array-based genetic maps with gene expression signatures derived from...
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