Article
Frequent mutations in the MITF pathway in melanoma.
Pigment cell & melanoma research - 1 Aug 2009
Cronin Julia C, Wunderlich John, Loftus Stacie K, Prickett Todd D, Wei Xiaomu, Ridd Katie, Vemula Swapna, Burrell Allison S, Agrawal Neena S, Lin Jimmy C, Banister Carolyn E, Buckhaults Phillip, Rosenberg Steven A, Bastian Boris C, Pavan William J, Samuels Yardena
Abstract excerpt
Microphthalmia-associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia. To determine whether MITF is somatically mutated in melanoma, we compared the sequence of MITF from primary and metastatic lesions to patient-matched normal DNA. In the 50 metastatic melanoma tumor lines analysed, we discovered four samples that had genomic amplifications of MITF and four...
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