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Article

A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo.

The Journal of investigative dermatology - 1 Jan 2014

Lister James A, Capper Amy, Zeng Zhiqiang, Mathers Marie E, Richardson Jennifer, Paranthaman Karthika, Jackson Ian J, Elizabeth Patton E

Abstract excerpt

The microphthalmia-associated transcription factor (MITF) is the "master melanocyte transcription factor" with a complex role in melanoma. MITF protein levels vary between and within clinical specimens, and amplifications and gain- and loss-of-function mutations have been identified in melanoma. How MITF functions in melanoma development and the effects of targeting MITF in vivo are unknown because MITF levels...

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Share to Melanocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microphthalmia-Associated Transcription Factor

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Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 23831555
DOI: 10.1038/jid.2013.293
PMCID: PMC3898314

Genes

MITF
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo.PMID 23831555Read ↗

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MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read ↗

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BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.Semantic proximity Read ↗

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KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.Semantic proximity Read ↗

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen speciesSemantic proximity Read ↗

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Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

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