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Article

Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal Melanoma

5 Nov 2010

Abstract excerpt

PURPOSE: MicroRNAs (miRNAs) can contribute to tumorigenesis by acting as either oncogenes or tumor suppressor genes. The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. In this study, they investigated the role of miR-137 in the pathogenesis of uveal melanoma. METHODS: Real-time RT-PCR was used to screen the expression levels of miR-137 in uveal melanocytes...

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PMID: 21051724
DOI: 10.1167/iovs.10-5272

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