Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.

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Article

Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.

The EMBO journal - 1 Oct 1996

Marklund U, Larsson N, Gradin H M, Brattsand G, Gullberg M

Abstract excerpt

Oncoprotein 18 (Op18, also termed p19, p18, prosolin or stathmin) is a cytosolic protein of previously unknown function. Phosphorylation of Op18 is cell cycle regulated by cyclin-dependent kinases (CDKs), and expression of a 'CDK target site-deficient mutant' results in a phenotype indicative of...

Topics

Amino Acid Sequence
Cadmium
Cell Cycle
Cyclin-Dependent Kinases
DNA, Neoplasm
Edetic Acid
Gene Expression Regulation
Humans
Leukemia, Erythroblastic, Acute
Metaphase
Microtubule Proteins
Microtubules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nocodazole

Paclitaxel

Phenotype

Phosphoproteins

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 8895574
PMCID: PMC452273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8895574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.PMID 8895574Read ↗

Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis.Semantic proximity Read ↗

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Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.Semantic proximity Read ↗

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The phenotype of a "Cdc2 kinase target site-deficient" mutant of oncoprotein 18 reveals a role of this protein in cell cycle control.Semantic proximity Read ↗

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